Use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) to detect carbapenemase production in Enterobacteriaceae by a rapid meropenem degradation assay.

نویسندگان

  • Claudio Foschi
  • Vincenzo Franza
  • Matteo Conti
  • Maria Vittoria Tamburini
  • Greta Roncarati
  • Miriam Cordovana
  • Viktoria Smirnova
  • Daniela Patrono
  • Rita Mancini
  • Maria Paola Landini
  • Simone Ambretti
چکیده

We evaluated the analytical performance of a liquid chromatography-tandem mass spectrometry assay to detect carbapenemase activity in a group of carbapenemase-producing Enterobacteriaceae by meropenem hydrolysis. This one-hour method showed a sensitivity of 94% and a specificity of 100%, representing a rapid and reliable option compared to conventional phenotypic assays.

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عنوان ژورنال:
  • The new microbiologica

دوره 38 4  شماره 

صفحات  -

تاریخ انتشار 2015